Synthesis of 1-AZA-Bicyclic Compounds
Undergraduate 项目
调查人员: Pier Cirillo, Lecturer of 化学, Lucia Moreno, Kyle Lambert
赞助商: Summer Undergraduate 研究 Fellowships 2010 and 2011.
项目 描述: For centuries, ancient Chinese medicine (Ku Shen) has employed the root of 摘要 刺蛾 in the treatment of various ailments such as diarrhea, jaundice, skin rashes, and to kill parasites. One of the major alkaloids of interest found within the root of the 摘要 plant is matrine (below), a compound containing 1-aza bicyclic structural motifs called quinolizidine.
Dr. Cirillo, a consultant for L 2 Diagnostics of New Haven, CT, is developing new iridium- or rhodium- catalyzed methodology for the synthesis of quinolizidines, with the aim to extend its application towards the synthesis of matrine and analogs.